Trivia: Which mastermind is the main antagonist in the Sherlock Holmes series?
Professor Presbury
Professor Moriarty
Doctor John Watson
Inspector Lestrade
The correct answer is Professor Moriarty
So why is this answer correct? : The ruthless villain Moriarty appeared throughout Sir Arthur Conan Doyle’s “Sherlock Holmes” tales, playing a central role in the stories “The Final Problem” and “The Valley of Fear.” Intelligent and calculated, Moriarty ruled the criminal underground in London and would not stop until he destroyed Holmes. While Holmes faced many villains in his time, Moriarty was by far his ultimate nemesis.