Trivia: John C. Calhoun became the first U.S. Vice President to do what?
Die in office
Defeat the sitting President
Resign
Get married in office
The correct answer is Resign
So why is this answer correct? : After navigating strong ideological differences with President Andrew Jackson, John C. Calhoun became the first Vice President to resign from office on December 28, 1832. After his resignation, Calhoun took a seat in the Senate where he continued to have a contentious relationship with President Jackson and his supporters. The only other Vice President to resign was Spiro Agnew, in 1973.